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Latest publications
A free, open-access library of high-quality organism illustrations for science communication
We create vector graphics of model organisms and emerging biological research organisms to enhance our publications. We’re sharing these editable graphics under a CC0 license for other scientists to use in figures, slides, teaching materials, or other outputs.
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How do we balance labor and yield in high-throughput protein expression?
We need to test hundreds of in silico protein variant designs in the lab. We have automated purification strategies, but expressing enough protein to purify is low-throughput and rate-limiting. Can we crank up expression without big, unwieldy culture flasks and intensive effort?
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Efficient GFP variant design with a simple neural network ensemble
We designed novel GFPs using a neural network ensemble. We quickly developed an experimental validation procedure in parallel, confirming that several candidates were functional. This rapid loop of in silico generation and lab validation may accelerate protein engineering.
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AutoOpenRaman: Low-cost, automated Raman spectroscopy
We developed AutoOpenRaman, an automated, inexpensive microscope for Raman spectroscopy. We recapitulated many features of expensive commercial Raman spectroscopy systems using economical hardware and open-source software.
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Automating identification and quantification of mouse scratch behavior in video recordings
Itch is a key symptom of many diseases. Drug development for these diseases requires assessing itch to determine if potential drugs work. We developed a workflow to rapidly quantify scratching, a measure of itch, in a pre-clinical animal model to speed drug discovery.
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Mapping the spectrum of archaeal protein sequence–structure relationships
We analyzed 4,064 Asgard protein families, seeking generalizable rules governing sequence–structure relationships. We found a subset of protein families with structural conservation despite phylogenetic and sequence diversity, but no global constraints across the proteome.
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