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We publish everything from ideas and perspectives to data, methods, protocols, and even research we put on ice.
Xanthate lysis yields high-throughput and high-molecular-weight DNA from _Chlamydomonas reinhardtii_ and _C. smithii_ strains.
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We added a helix penalty that shifted ESMFold2 binder designs toward β-sheets across five targets. The shift began early in optimization and increased the number passing a sheet-content and confidence screen, despite lower average confidence.
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Transformers trained on planetary orbits can predict planet movement with high fidelity under multiple possible “world models.” Here, we apply equivalent linear mapping to precisely characterize how a transformer builds its predictions from two past planetary positions.
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We present a reusable, cloud-scalable pipeline that pairs Cellpose-SAM segmentation with on-demand GPU compute for single-cell phenotyping of high-content microscopy, demonstrated on a two-species yeast panel (_S. cerevisiae_ versus _S. pombe_).
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Comparing the geometry of RNA, protein, and growth measurements in natural yeast strains, we find that each biological layer reorganizes the shape of phenotypic variation in a distinct way. Phenotypic geometry is a property that must be measured rather than assumed.
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There's no reliable recipe for getting cells to express a recombinant protein, but there's a faster way to find out whether yours will. We propose a roadmap to compress a months-long expression campaign into about a month, with a clear decision point at the end.
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