Leveraging evolution to engineer biology

We're testing an evolution-based drug discovery model
with an iterative loop of computational prediction
and experimental validation.

Target identification

Mining billions of years of evolution to systematize target discovery

We integrate across evolutionary scales to identify the causal bases of biological traits.

Model selection

Improving outcomes by picking useful research organisms

We're applying our platform to match disease biology with the most human relevant organisms.

Biologics design

Designing proteins from evolutionary principles

We develop statistical models to predict fitness and function. Our closed loop lets us experimentally test predictions and iterate on our models.

Technology development

Building assays and tools to test our predictions

We're developing and deploying organism-agnostic tools to investigate disease mechanisms.

Target identification

Mining billions of years of evolution to systematize target discovery

We integrate across evolutionary scales to identify the causal bases of biological traits.

Model selection

Improving outcomes by picking useful research organisms

We're applying our platform to match disease biology with the most human relevant organisms.

Biologics design

Designing proteins from evolutionary principles

We develop statistical models to predict fitness and function. Our closed loop lets us experimentally test predictions and iterate on our models.

Technology development

Building assays and tools to test our predictions

We're developing and deploying organism-agnostic tools to investigate disease mechanisms.

We publish our work and release open-source tools and resources for the scientific community.

Use our tools

Check out our latest research

resource24 Feb 2026

Coherent Raman imaging of live, unfixed _Saccharomyces cerevisiae_ and mutants _aah1∆ and rad6∆_

We acquired single-cell coherent Raman microscopy data (SRS and CARS) from wild-type budding yeast and two mutants. Our aim was to collect spatially resolved biochemical data on living yeast cells. We’re sharing the data and code for others to visualize and explore it!

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observation19 Feb 2026

Morphological transformation of _Chlamydomonas smithii_ grown in Marine Broth medium

Marine Broth induces extreme morphological transformation in _C. smithii_: Cells shift from typical ellipsoid shape to amorphous forms with thin wisp-like appendages containing mitochondria, revealing unexpected cellular plasticity.

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resource12 Feb 2026

A tractability atlas for experimental organism selection

We’ve mapped experimental tractability for ~15,000 diverse organisms. By aggregating data on community activity, infrastructure, tooling, throughput, and logistics, our interactive atlas helps researchers navigate trade-offs when deciding which organisms to use for their work.

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